Assessment of Subclinical Myocardial Changes in Non-Alcoholic Fatty Liver Disease: A Case-Control Study Using Speckle Tracking Echocardiography

Authors

  • Alireza Moaref Cardiovascular Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  • Ehsan Samiee Cardiovascular Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  • Firoozeh Abtahi Cardiovascular Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  • Mahmood Zamirian Cardiovascular Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  • Maryam Tahamtan Cardiovascular Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract:

Background: Considering the association between cardiac abnormalities and non-alcoholic fatty liver disease (NAFLD), the present study aimed to evaluate the relationship between biopsy-proven NAFLD and functional echocardiographic parameters, including left ventricular (LV) global longitudinal strain (GLS) in asymptomatic individuals. Methods: Thirty asymptomatic patients with liver biopsy-proven NAFLD and the same number with no evidence of fatty liver in ultrasonography were enrolled in the study as cases and controls, respectively. The measured echocardiographic parameters included LV ejection fraction (LVEF), LV end-systolic and end-diastolic dimensions (ESD, EDD), LV end-systolic and end-diastolic volumes (ESV, EDV), E/e’ ratio (early-diastolic mitral inflow velocity/early-diastolic myocardial velocity), E/A ratio (early-diastolic mitral inflow velocity/late-diastolic mitral inflow velocity), and GLS. Data were analyzed using the SPSS statistical software (version 18.0) by performing the independent t test, Chi-square, and non-parametric Mann-Whitney U tests. P values <0.05 were considered statistically significant. Results: A significant difference in ESD (32.1±1.4 mm vs. 34±1.8 mm), EDD (41.9±1.7 mm vs. 45.2±3.1 mm), and E/e’ ratio (8.4±0.8 vs. 7.4±1.2) was detected among individuals with NAFLD compared with those without NAFLD (P<0.001 for the first two parameters and P=0.002 for the last one). GLS was also significantly lower in NAFLD patients than in controls, but within normal levels (19.3%±2.0 vs. 21.2%±1.4, P<0.001). Conclusion: The findings support the presence of subclinical cardiovascular structural and functional changes in patients affected by NAFLD. It also indicates that the use of GLS is more sensitive than LVEF for the detection of LV systolic dysfunction in NAFLD patients.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Prevalence of gallstone disease in the patients with non-alcoholic fatty liver disease (NAFLD) in Sanandaj: A case control study

Background and Aim: Nonalcoholic fatty liver disease (NAFLD) and gallstone disease (GD) are both highly prevalent in the general population and have many risk factors in common. The aim of this study was to evaluate the prevalence of GD in the patients with NAFLD. Materials and Methods: In this case-control study, our case group included 145 patients with NAFLD and control group consisted of 21...

full text

Evaluation of the effects of resveratrol on non-alcoholic fatty liver disease A systematic review study

Introduction: Non-alcoholic fatty liver disease (NAFLD) is a condition in which triglycerides accumulate in liver cells without a history of alcohol consumption. Evidence has shown that auxiliary treatments, including the use of antioxidant compounds, can be effective in improving nonalcoholic fatty liver. Resveratrol is an antioxidant compound that has been shown to be beneficial in some disea...

full text

Fast Food Consumption and the Risk of Non-Alcoholic Fatty Liver in Adults: A Community-Based Case-Control Study

Background: Despite many studies showing a correlation between fast food consumption and non-alcoholic fatty liver disease (NAFLD) known as the silent death, few studies have investigated the effects of different types of fast foods on this disease. This research aimed to evaluate the effect of consuming different types of fast foods on non-alcoholic fatty liver disease. Materials and Methods:...

full text

Clinical Manifestations and Diagnosis of Non-Alcoholic Fatty Liver Disease

Background & Objective: Nonalcoholic fatty liver diseases (NAFLD) is the major cause of hepatocellular carcinoma and increases the risk of mortality. Understanding the trends of its clinical and biochemical changes is essential to identify patients with NAFLD that are at the greatest risk of nonalcoholic steatohepatitis (NASH) and cirrhosis in Iran. M...

full text

The Effect of GeriLact on Non-Alcoholic Fatty Liver Disease

Background: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease which is correlated with overweight, obesity, and insulin resistance. Recently, the use of probiotics has been suggested for these patients as they have considerable outcomes. The aim of the present study is to evaluate the effect of GeriLact on patients with NAFLD. Method:</...

full text

The Efficacy of Silymarin and Vitamin E in Non-Alcoholic Fatty Liver Disease: A Clinical Trial

Abstract Objective: Nowadays, lifestyle modification is the best treatment recommended to patients with the nonalcoholic fatty liver disease (NAFLD). The therapeutic effects of vitamin E and silybin on liver functions were documented. The present study was conducted to examine the effect of silymarin and vitamin E on patients with NAFLD. Materials and Methods: From September 2014 to March 201...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 43  issue 5

pages  466- 472

publication date 2018-09-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023